Coenzyme Q10

Increased oxidative stress is implicated in the pathogenesis of age-related neurodegenerative diseases. CoQ10 reduces oxidative stress and amyloid pathology and improves behavioral performance in the mouse models of Alzheimer’s disease. CoQ10 treatment decreases brain levels of protein carbonyls, a marker of oxidative stress. CoQ10 treatment resulted in decreased plaque area and number in hippocampus and in overlying cortex.